The 10pm airing is the first instance of the series that day.
If I set it to "first run only" it records the 10pm broadcast as well as the 11pm broadcast. Given that this is a daily newscast, I am not sure it qualifies as "first run". It does not indicate in the guide as such. There is no "original air date" listed.
BTW the program I am referring to is "CTV National News with Lisa LaFlamme" that airs on CTV News Channel at 10pm and repeats 11pm.